Payment overview · 2025
General Payments
$659.78
20 reported records · 10 companies
Healthcare provider profile · identity verified
William D Largen, MD
Allopathic & Osteopathic Physicians|Internal Medicine|Infectious Disease · SUMMERVILLE, SC · NPI 1336435205
Verified facts
What the public records show
CMS Open Payments records show William D Largen, MD received $659.78 in general payments during 2025 across 20 reported records.
Shionogi Inc accounted for 28.4% of that reported general-payment amount.
The Open Payments records used for this analysis explicitly named 12 associated products.
A separate comparison found the same explicitly named product in public Medicare Part D data: Nuzyra.
Gilead Sciences, Inc. reported payments to this doctor in 2025. Across the 2025 Open Payments General Payment records loaded for this analysis, that same reporting entity reported Biktarvy as an associated drug or biological on 8065 records involving 2759 distinct recipient NPIs. Public Medicare Part D data also shows 33 claims for Biktarvy by this doctor in 2024.
Paratek Pharmaceuticals, Inc. reported payments to this doctor in 2025. Across the 2025 Open Payments General Payment records loaded for this analysis, that same reporting entity reported NUZYRA as an associated drug or biological on 24089 records involving 10216 distinct recipient NPIs. Public Medicare Part D data also shows 11 claims for Nuzyra by this doctor in 2024.
These records do not establish that a payment influenced prescribing or medical care.
Separate record types
Research & Ownership
Research Payments (direct recipient): not present in the loaded data
Associated Research Funding (for example, named PI): not present in the loaded data
Ownership / Investment: not present in the loaded data
These categories are never added into the General Payments headline. Associated research funding must not be described as money the doctor personally received unless the source record supports that conclusion.
Who paid this doctor?
Companies in 2025 General Payments
| Reported company | Canonical company | Amount | Share | Records | Year |
|---|---|---|---|---|---|
| Shionogi Inc | Unresolved — no canonical attribution shown | $187.47 | 28.4% | 3 | 2025 |
| Aimmune Therapeutics, Inc. | Unresolved — no canonical attribution shown | $121.47 | 18.4% | 3 | 2025 |
| Merck Sharp & Dohme LLC | Unresolved — no canonical attribution shown | $71.51 | 10.8% | 3 | 2025 |
| Insmed, Inc. | Unresolved — no canonical attribution shown | $66.87 | 10.1% | 2 | 2025 |
| ViiV Healthcare Company | Unresolved — no canonical attribution shown | $66.07 | 10.0% | 3 | 2025 |
| Cumberland Pharmaceuticals, Inc. | Unresolved — no canonical attribution shown | $47.22 | 7.2% | 2 | 2025 |
| Gilead Sciences, Inc. | Unresolved — no canonical attribution shown | $31.78 | 4.8% | 1 | 2025 |
| CorMedix Inc. | Unresolved — no canonical attribution shown | $28.65 | 4.3% | 1 | 2025 |
| Melinta Therapeutics, LLC | Unresolved — no canonical attribution shown | $23.28 | 3.5% | 1 | 2025 |
| Paratek Pharmaceuticals, Inc. | Unresolved — no canonical attribution shown | $15.46 | 2.3% | 1 | 2025 |
What were the payments for?
Payment categories
| Category | Amount | Records |
|---|---|---|
| Food and Beverage | $634.08 | 19 |
| Education | $25.70 | 1 |
A meal, consulting fee, royalty, and travel payment describe different kinds of reported relationships and should not be interpreted as equivalent.
Analysis 1 · Payment-linked products
Products named in Open Payments records
| Reported product | Type | Reported company | Related amount* | Records | Year |
|---|---|---|---|---|---|
| Fetroja Normalized: fetroja |
Drug | Shionogi Inc | $187.47 | 3 | 2025 |
Source payment records
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| ZENPEP Normalized: zenpep |
Drug | Aimmune Therapeutics, Inc. | $72.11 | 1 | 2025 |
Source payment records
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| Arikayce Normalized: arikayce |
Drug | Insmed, Inc. | $66.87 | 2 | 2025 |
Source payment records
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| VOWST Normalized: vowst |
Biological | Aimmune Therapeutics, Inc. | $49.36 | 2 | 2025 |
Source payment records
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| ZERBAXA Normalized: zerbaxa |
Drug | Merck Sharp & Dohme LLC | $47.77 | 2 | 2025 |
Source payment records
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| VIBATIV Normalized: vibativ |
Drug | Cumberland Pharmaceuticals, Inc. | $47.22 | 2 | 2025 |
Source payment records
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| RUKOBIA Normalized: rukobia |
Drug | ViiV Healthcare Company | $33.58 | 2 | 2025 |
Source payment records
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| DOVATO Normalized: dovato |
Drug | ViiV Healthcare Company | $32.49 | 1 | 2025 |
Source payment records
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| DEFENCATH Normalized: defencath |
Drug | CorMedix Inc. | $28.65 | 1 | 2025 |
Source payment records
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| PIFELTRO Normalized: pifeltro |
Drug | Merck Sharp & Dohme LLC | $23.74 | 1 | 2025 |
Source payment records
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| Rezzayo Normalized: rezzayo |
Drug | Melinta Therapeutics, LLC | $23.28 | 1 | 2025 |
Source payment records
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| NUZYRA Normalized: nuzyra |
Drug | Paratek Pharmaceuticals, Inc. | $15.46 | 1 | 2025 |
Source payment records
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* Product-associated amounts are non-additive because one payment record may name more than one product.
These products were named on specific Open Payments records. A named product does not show that the payment influenced treatment or prescribing.
Public prescribing for products named in payments
| Open Payments product | Payment year | Part D brand | Part D year | Claims | Match method | Source |
|---|---|---|---|---|---|---|
| NUZYRA nuzyra |
2025 | Nuzyra | 2024 | 11 Beneficiary count suppressed |
exact normalized | Medicare Part D |
The presence of the same drug in both datasets does not show that a payment caused or influenced a prescription.
Analysis 2 · Same-company prescribing overlap
Drugs reported in other payments from the same company that also appear in Medicare Part D
This analysis is independent from products named on this doctor’s individual payment records. A row appears only when the exact Open Payments reporting entity paid this doctor, that same reporting entity reported the drug or biological on at least 10 loaded General Payment records involving at least 2 distinct recipient NPIs, and this doctor has the same non-generic brand in public Part D data. This does not mean the company owns or manufactures the drug.
| Paying company | Payment year | Drug reported by same entity | Open Payments evidence | Part D | Claims | Beneficiaries |
|---|---|---|---|---|---|---|
| Gilead Sciences, Inc. Exact reporting entity; no affiliate inference |
2025 | Biktarvy open payments reported associated product |
CMS Open Payments — General Payments 8065 supporting records · 2759 recipient NPIs · example record 1234350766 |
Biktarvy · 2024 Exact normalized brand match · 1 Part D row |
33 | suppressed by CMS |
| Paratek Pharmaceuticals, Inc. Exact reporting entity; no affiliate inference |
2025 | NUZYRA open payments reported associated product |
CMS Open Payments — General Payments 24089 supporting records · 10216 recipient NPIs · example record 1181734338 |
Nuzyra · 2024 Exact normalized brand match · 1 Part D row |
11 | suppressed by CMS |
These facts do not show that a payment was for the drug, that the company owns or manufactures the drug, or that a payment caused or influenced prescribing.
Public Medicare Part D data
Provider-and-drug rows loaded for 2024
| Brand | Generic | Claims | Beneficiaries |
|---|---|---|---|
| Ceftriaxone | Ceftriaxone Sodium | 86 | 13 |
| Vancomycin Hcl | Vancomycin Hcl | 81 | 22 |
| Cefoxitin | Cefoxitin Sodium | 65 | suppressed |
| Doxycycline Hyclate | Doxycycline Hyclate | 44 | 16 |
| Biktarvy | Bictegrav/Emtricit/Tenofov Ala | 33 | suppressed |
| Cefepime Hcl | Cefepime Hcl | 28 | suppressed |
| Azithromycin | Azithromycin | 27 | suppressed |
| Ciprofloxacin Hcl | Ciprofloxacin Hcl | 24 | 15 |
| Rifampin | Rifampin | 21 | suppressed |
| Ethambutol Hcl | Ethambutol Hcl | 20 | suppressed |
| Amoxicillin-Clavulanate Potass | Amoxicillin/Potassium Clav | 18 | 11 |
| Daptomycin | Daptomycin | 16 | suppressed |
| Genvoya | Elviteg/Cob/Emtri/Tenof Alafen | 14 | suppressed |
| Piperacillin-Tazobactam | Piperacillin Sodium/Tazobactam | 13 | suppressed |
| Ertapenem | Ertapenem Sodium | 12 | suppressed |
| Amoxicillin | Amoxicillin | 11 | suppressed |
| Moxifloxacin Hcl | Moxifloxacin Hcl | 11 | suppressed |
| Nuzyra | Omadacycline Tosylate | 11 | suppressed |
Timeline
Payment and prescribing data by year
Open Payments and Medicare Part D may refer to different years. They are shown separately rather than aligned as if they describe the same period.
| Year | General Payments | Main payer | Explicit products | Company overlaps | Part D coverage |
|---|---|---|---|---|---|
| 2025 | $659.78 · 20 records | Shionogi Inc | Arikayce, DEFENCATH, DOVATO, Fetroja, NUZYRA, PIFELTRO, RUKOBIA, Rezzayo, VIBATIV, VOWST, ZENPEP, ZERBAXA | 2 | — |
| 2024 | — | — | — | — | Complete |
Questions to ask
Questions you could discuss with your doctor
- What role, if any, does Nuzyra play in your treatment recommendations for me?
- How do you evaluate evidence when you have a financial relationship with Gilead Sciences, Inc.?
- Are there reasonable alternatives I should understand when we discuss treatment options?
- How should I interpret the industry-payment records shown here in the context of my care?
These are general questions generated from reviewed templates. They are not personalized medical advice.
Sources and limitations
How to read this page
- Payment and Medicare prescribing data can cover different years; every comparison shows both years explicitly.
- Part D does not represent a doctor’s entire practice; it excludes many patients and is subject to CMS public-release thresholds.
- Company–drug relationships must have an auditable source, a precise relationship type, and a valid evidence period. Unresolved mappings are not published.
- Generic drug claims are not attributed to a specific manufacturer without manufacturer-level evidence.
- When a source extract is incomplete, missing rows are never treated as proof of no payments or no prescriptions.
Loaded source releases
| Dataset | Year | Publication | Source |
|---|---|---|---|
| CMS Open Payments — General Payments | 2025 | 2026-06-30 | Original source |
| Medicare Part D Prescribers by Provider and Drug | 2024 | 2026-05-06 | Original source |
| NPPES Data Dissemination V2 | current / reference data | 2026-08-10 | Original source |
Full methodology · Questions & answers · Report a possible error