Payment overview · 2025
General Payments
$353,239.16
64 reported records · 23 companies
Healthcare provider profile · identity verified
Isaac Melamed, M.D.
Allopathic & Osteopathic Physicians|General Practice · CENTENNIAL, CO · NPI 1366480816
Verified facts
What the public records show
CMS Open Payments records show Isaac Melamed, M.D. received $353,239.16 in general payments during 2025 across 64 reported records.
Octapharma USA, Inc. accounted for 96.5% of that reported general-payment amount.
The Open Payments records used for this analysis explicitly named 24 associated products.
AstraZeneca Pharmaceuticals LP reported payments to this doctor in 2025. Across the 2025 Open Payments General Payment records loaded for this analysis, that same reporting entity reported SYMBICORT as an associated drug or biological on 71 records involving 51 distinct recipient NPIs. Public Medicare Part D data also shows 18 claims for Symbicort by this doctor in 2024.
These records do not establish that a payment influenced prescribing or medical care.
Separate record types
Research & Ownership
Research Payments (direct recipient): not present in the loaded data
Associated Research Funding (for example, named PI): not present in the loaded data
Ownership / Investment: not present in the loaded data
These categories are never added into the General Payments headline. Associated research funding must not be described as money the doctor personally received unless the source record supports that conclusion.
Who paid this doctor?
Companies in 2025 General Payments
| Reported company | Canonical company | Amount | Share | Records | Year |
|---|---|---|---|---|---|
| Octapharma USA, Inc. | Unresolved — no canonical attribution shown | $340,770.02 | 96.5% | 4 | 2025 |
| Consortium of Independent Immunology Clinics, LLC | Unresolved — no canonical attribution shown | $10,000.00 | 2.8% | 1 | 2025 |
| Pharming Healthcare, Inc. | Unresolved — no canonical attribution shown | $1,209.50 | 0.3% | 12 | 2025 |
| Takeda Pharmaceuticals U.S.A., Inc. | Unresolved — no canonical attribution shown | $232.38 | 0.1% | 3 | 2025 |
| BioCryst US Sales Co., LLC | Unresolved — no canonical attribution shown | $165.49 | 0.1% | 9 | 2025 |
| GENZYME CORPORATION | Unresolved — no canonical attribution shown | $130.79 | 0.0% | 2 | 2025 |
| Ionis Pharmaceuticals, Inc. | Unresolved — no canonical attribution shown | $125.02 | 0.0% | 5 | 2025 |
| Cycle Pharmaceuticals Inc | Unresolved — no canonical attribution shown | $104.29 | 0.0% | 4 | 2025 |
| Novartis Pharmaceuticals Corporation | Unresolved — no canonical attribution shown | $69.92 | 0.0% | 4 | 2025 |
| Genentech USA, Inc. | Unresolved — no canonical attribution shown | $67.97 | 0.0% | 3 | 2025 |
| Galderma Laboratories, L.P. | Unresolved — no canonical attribution shown | $53.23 | 0.0% | 3 | 2025 |
| GlaxoSmithKline, LLC. | Unresolved — no canonical attribution shown | $40.28 | 0.0% | 2 | 2025 |
| TerSera Therapeutics LLC | Unresolved — no canonical attribution shown | $38.45 | 0.0% | 1 | 2025 |
| Neurelis, Inc. |
Neurelis, Inc. exact · evidence 2025-02-20 |
$37.04 | 0.0% | 1 | 2025 |
| GC Biopharma USA, Inc. | Unresolved — no canonical attribution shown | $32.90 | 0.0% | 2 | 2025 |
| CSL Behring | Unresolved — no canonical attribution shown | $32.26 | 0.0% | 1 | 2025 |
| Grifols USA, LLC | Unresolved — no canonical attribution shown | $26.47 | 0.0% | 1 | 2025 |
| AstraZeneca Pharmaceuticals LP | Unresolved — no canonical attribution shown | $24.52 | 0.0% | 1 | 2025 |
| Blueprint Medicines Corporation | Unresolved — no canonical attribution shown | $22.35 | 0.0% | 1 | 2025 |
| Amgen Inc. | Unresolved — no canonical attribution shown | $20.74 | 0.0% | 1 | 2025 |
| PFIZER INC. | Unresolved — no canonical attribution shown | $14.76 | 0.0% | 1 | 2025 |
| X4 Pharmaceuticals, Inc. | Unresolved — no canonical attribution shown | $14.32 | 0.0% | 1 | 2025 |
| ADMA BioManufacturing LLC | Unresolved — no canonical attribution shown | $6.46 | 0.0% | 1 | 2025 |
What were the payments for?
Payment categories
| Category | Amount | Records |
|---|---|---|
| Compensation for services other than consulting, including serving as faculty or as a speaker at a venue other than a continuing education program | $340,678.75 | 3 |
| Consulting Fee | $10,006.46 | 2 |
| Food and Beverage | $2,553.95 | 59 |
A meal, consulting fee, royalty, and travel payment describe different kinds of reported relationships and should not be interpreted as equivalent.
Analysis 1 · Payment-linked products
Products named in Open Payments records
| Reported product | Type | Reported company | Related amount* | Records | Year |
|---|---|---|---|---|---|
| CUTAQUIG Normalized: cutaquig |
Biological | Octapharma USA, Inc. | $221,550.00 | 2 | 2025 |
Source payment records
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| OCTAGAM IMMUNE GLOBULIN (HUMAN) Normalized: octagam immune globulin human |
Biological | Octapharma USA, Inc. | $119,128.75 | 1 | 2025 |
Source payment records
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| RUCONEST Normalized: ruconest |
Biological | Pharming Healthcare, Inc. | $1,084.50 | 11 | 2025 |
Source payment records
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| TAKHZYRO Normalized: takhzyro |
Biological | Takeda Pharmaceuticals U.S.A., Inc. | $218.18 | 2 | 2025 |
Source payment records
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| ORLADEYO Normalized: orladeyo |
Drug | BioCryst US Sales Co., LLC | $165.49 | 9 | 2025 |
Source payment records
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| AYVAKIT Normalized: ayvakit |
Biological, Drug | Blueprint Medicines Corporation, GENZYME CORPORATION | $153.14 | 3 | 2025 |
Source payment records
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| PANZYGA Normalized: panzyga |
Biological | Octapharma USA, Inc., PFIZER INC. | $106.03 | 2 | 2025 |
Source payment records
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| Sajazir Normalized: sajazir |
Drug | Cycle Pharmaceuticals Inc | $104.29 | 4 | 2025 |
Source payment records
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| XOLAIR Normalized: xolair |
Biological, Drug | Genentech USA, Inc., Novartis Pharmaceuticals Corporation | $71.22 | 3 | 2025 |
Source payment records
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| DAWNZERA Normalized: dawnzera |
Drug | Ionis Pharmaceuticals, Inc. | $56.89 | 2 | 2025 |
Source payment records
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| NEMLUVIO Normalized: nemluvio |
Drug | Galderma Laboratories, L.P. | $53.23 | 3 | 2025 |
Source payment records
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| Quzyttir Normalized: quzyttir |
Drug | TerSera Therapeutics LLC | $38.45 | 1 | 2025 |
Source payment records
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| VALTOCO Normalized: valtoco |
Drug | Neurelis, Inc. | $37.04 | 1 | 2025 |
Source payment records
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| ALYGLO Normalized: alyglo |
Drug | GC Biopharma USA, Inc. | $32.90 | 2 | 2025 |
Source payment records
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| Hizentra Normalized: hizentra |
Biological | CSL Behring | $32.26 | 1 | 2025 |
Source payment records
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| TRELEGY ELLIPTA Normalized: trelegy ellipta |
Drug | GlaxoSmithKline, LLC. | $26.78 | 1 | 2025 |
Source payment records
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| Xembify Normalized: xembify |
Biological | Grifols USA, LLC | $26.47 | 1 | 2025 |
Source payment records
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| FASENRA Normalized: fasenra |
Biological | AstraZeneca Pharmaceuticals LP | $24.52 | 1 | 2025 |
Source payment records
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| TAVNEOS Normalized: tavneos |
Drug | Amgen Inc. | $20.74 | 1 | 2025 |
Source payment records
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| Ocrevus Zunovo Normalized: ocrevus zunovo |
Biological | Genentech USA, Inc. | $19.17 | 1 | 2025 |
Source payment records
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| Rhapsido Normalized: rhapsido |
Drug | Novartis Pharmaceuticals Corporation | $15.08 | 1 | 2025 |
Source payment records
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| XOLREMDI Normalized: xolremdi |
Drug | X4 Pharmaceuticals, Inc. | $14.32 | 1 | 2025 |
Source payment records
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| ARALAST Normalized: aralast |
Biological | Takeda Pharmaceuticals U.S.A., Inc. | $14.20 | 1 | 2025 |
Source payment records
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| NUCALA Normalized: nucala |
Biological | GlaxoSmithKline, LLC. | $13.50 | 1 | 2025 |
Source payment records
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* Product-associated amounts are non-additive because one payment record may name more than one product.
These products were named on specific Open Payments records. A named product does not show that the payment influenced treatment or prescribing.
Public prescribing for products named in payments
No exact normalized or approved-alias overlap was found in the loaded Part D year. This does not mean the doctor never prescribed the product.
The presence of the same drug in both datasets does not show that a payment caused or influenced a prescription.
Analysis 2 · Same-company prescribing overlap
Drugs reported in other payments from the same company that also appear in Medicare Part D
This analysis is independent from products named on this doctor’s individual payment records. A row appears only when the exact Open Payments reporting entity paid this doctor, that same reporting entity reported the drug or biological on at least 10 loaded General Payment records involving at least 2 distinct recipient NPIs, and this doctor has the same non-generic brand in public Part D data. This does not mean the company owns or manufactures the drug.
| Paying company | Payment year | Drug reported by same entity | Open Payments evidence | Part D | Claims | Beneficiaries |
|---|---|---|---|---|---|---|
| AstraZeneca Pharmaceuticals LP Exact reporting entity; no affiliate inference |
2025 | SYMBICORT open payments reported associated product |
CMS Open Payments — General Payments 71 supporting records · 51 recipient NPIs · example record 1206132610 |
Symbicort · 2024 Exact normalized brand match · 1 Part D row |
18 | suppressed by CMS |
These facts do not show that a payment was for the drug, that the company owns or manufactures the drug, or that a payment caused or influenced prescribing.
Public Medicare Part D data
Provider-and-drug rows loaded for 2024
| Brand | Generic | Claims | Beneficiaries |
|---|---|---|---|
| Azithromycin | Azithromycin | 44 | 26 |
| Hydroxychloroquine Sulfate | Hydroxychloroquine Sulfate | 40 | 19 |
| Cromolyn Sodium | Cromolyn Sodium | 34 | 12 |
| Montelukast Sodium | Montelukast Sodium | 29 | 11 |
| Nitazoxanide | Nitazoxanide | 28 | 14 |
| Levocetirizine Dihydrochloride | Levocetirizine Dihydrochloride | 23 | suppressed |
| Doxycycline Hyclate | Doxycycline Hyclate | 21 | 11 |
| Cholestyramine | Cholestyramine (With Sugar) | 19 | 11 |
| Diphenhydramine Hcl | Diphenhydramine Hcl | 19 | suppressed |
| Symbicort | Budesonide/Formoterol Fumarate | 18 | suppressed |
| Ondansetron Hcl | Ondansetron Hcl/Pf | 17 | suppressed |
| Valacyclovir | Valacyclovir Hcl | 17 | suppressed |
| Dupixent Syringe | Dupilumab | 15 | suppressed |
| Breo Ellipta | Fluticasone/Vilanterol | 14 | suppressed |
| Oseltamivir Phosphate | Oseltamivir Phosphate | 12 | suppressed |
| Armour Thyroid | Thyroid,pork | 11 | suppressed |
| Dapsone | Dapsone | 11 | suppressed |
| Levothyroxine Sodium | Levothyroxine Sodium | 11 | suppressed |
Timeline
Payment and prescribing data by year
Open Payments and Medicare Part D may refer to different years. They are shown separately rather than aligned as if they describe the same period.
| Year | General Payments | Main payer | Explicit products | Company overlaps | Part D coverage |
|---|---|---|---|---|---|
| 2025 | $353,239.16 · 64 records | Octapharma USA, Inc. | ALYGLO, ARALAST, AYVAKIT, CUTAQUIG, DAWNZERA, FASENRA, Hizentra, NEMLUVIO, NUCALA, OCTAGAM IMMUNE GLOBULIN (HUMAN), ORLADEYO, Ocrevus Zunovo, PANZYGA, Quzyttir, RUCONEST, Rhapsido, Sajazir, TAKHZYRO, TAVNEOS, TRELEGY ELLIPTA, VALTOCO, XOLAIR, XOLREMDI, Xembify | 1 | — |
| 2024 | — | — | — | — | Complete |
Questions to ask
Questions you could discuss with your doctor
- How do you evaluate evidence when you have a financial relationship with AstraZeneca Pharmaceuticals LP?
- Are there reasonable alternatives I should understand when we discuss treatment options?
- How should I interpret the industry-payment records shown here in the context of my care?
These are general questions generated from reviewed templates. They are not personalized medical advice.
Sources and limitations
How to read this page
- Payment and Medicare prescribing data can cover different years; every comparison shows both years explicitly.
- Part D does not represent a doctor’s entire practice; it excludes many patients and is subject to CMS public-release thresholds.
- Company–drug relationships must have an auditable source, a precise relationship type, and a valid evidence period. Unresolved mappings are not published.
- Generic drug claims are not attributed to a specific manufacturer without manufacturer-level evidence.
- When a source extract is incomplete, missing rows are never treated as proof of no payments or no prescriptions.
Loaded source releases
| Dataset | Year | Publication | Source |
|---|---|---|---|
| CMS Open Payments — General Payments | 2025 | 2026-06-30 | Original source |
| Medicare Part D Prescribers by Provider and Drug | 2024 | 2026-05-06 | Original source |
| NPPES Data Dissemination V2 | current / reference data | 2026-08-10 | Original source |
Full methodology · Questions & answers · Report a possible error