Payment overview · 2025
General Payments
$496.96
21 reported records · 17 companies
Healthcare provider profile · identity verified
James Cooper Brien, M.D.
Allopathic & Osteopathic Physicians|Urology · ASHEVILLE, NC · NPI 1538383658
Verified facts
What the public records show
CMS Open Payments records show James Cooper Brien, M.D. received $496.96 in general payments during 2025 across 21 reported records.
Bayer Healthcare Pharmaceuticals Inc. accounted for 22.1% of that reported general-payment amount.
The Open Payments records used for this analysis explicitly named 16 associated products.
A separate comparison found the same explicitly named product in public Medicare Part D data: Xtandi.
Astellas Pharma US Inc reported payments to this doctor in 2025. Across the 2025 Open Payments General Payment records loaded for this analysis, that same reporting entity reported Myrbetriq as an associated drug or biological on 16 records involving 16 distinct recipient NPIs. Public Medicare Part D data also shows 152 claims for Myrbetriq by this doctor in 2024.
Astellas Pharma US Inc reported payments to this doctor in 2025. Across the 2025 Open Payments General Payment records loaded for this analysis, that same reporting entity reported Xtandi as an associated drug or biological on 11345 records involving 5418 distinct recipient NPIs. Public Medicare Part D data also shows 12 claims for Xtandi by this doctor in 2024.
Sumitomo Pharma America, Inc. reported payments to this doctor in 2025. Across the 2025 Open Payments General Payment records loaded for this analysis, that same reporting entity reported GEMTESA as an associated drug or biological on 61692 records involving 22152 distinct recipient NPIs. Public Medicare Part D data also shows 147 claims for Gemtesa by this doctor in 2024.
These records do not establish that a payment influenced prescribing or medical care.
Separate record types
Research & Ownership
Research Payments (direct recipient): not present in the loaded data
Associated Research Funding (for example, named PI): not present in the loaded data
Ownership / Investment: not present in the loaded data
These categories are never added into the General Payments headline. Associated research funding must not be described as money the doctor personally received unless the source record supports that conclusion.
Who paid this doctor?
Companies in 2025 General Payments
| Reported company | Canonical company | Amount | Share | Records | Year |
|---|---|---|---|---|---|
| Bayer Healthcare Pharmaceuticals Inc. | Unresolved — no canonical attribution shown | $109.65 | 22.1% | 1 | 2025 |
| Astellas Pharma US Inc | Unresolved — no canonical attribution shown | $52.80 | 10.6% | 2 | 2025 |
| Janssen Biotech, Inc. | Unresolved — no canonical attribution shown | $51.40 | 10.3% | 2 | 2025 |
| Endo USA, Inc. | Unresolved — no canonical attribution shown | $49.30 | 9.9% | 2 | 2025 |
| ABBVIE INC. | Unresolved — no canonical attribution shown | $25.14 | 5.1% | 1 | 2025 |
| Smith+Nephew, Inc. | Unresolved — no canonical attribution shown | $23.83 | 4.8% | 1 | 2025 |
| BIOPROTECT MEDICAL, INC. | Unresolved — no canonical attribution shown | $23.20 | 4.7% | 1 | 2025 |
| Procept Biorobotics Corporation | Unresolved — no canonical attribution shown | $22.24 | 4.5% | 1 | 2025 |
| Medtronic, Inc. |
Medtronic, Inc. exact · evidence 2025-07-22 |
$18.85 | 3.8% | 1 | 2025 |
| Sumitomo Pharma America, Inc. | Unresolved — no canonical attribution shown | $18.08 | 3.6% | 1 | 2025 |
| Ferring Pharmaceuticals Inc. | Unresolved — no canonical attribution shown | $17.24 | 3.5% | 1 | 2025 |
| Calyxo, Inc. | Unresolved — no canonical attribution shown | $17.02 | 3.4% | 1 | 2025 |
| PROGENICS PHARMACEUTICALS, INC. | Unresolved — no canonical attribution shown | $16.79 | 3.4% | 1 | 2025 |
| AngioDynamics, Inc. | Unresolved — no canonical attribution shown | $16.66 | 3.4% | 1 | 2025 |
| Boston Scientific Corporation | Unresolved — no canonical attribution shown | $16.40 | 3.3% | 1 | 2025 |
| Laborie Medical Technologies Corp. | Unresolved — no canonical attribution shown | $15.34 | 3.1% | 1 | 2025 |
| Travere Therapeutics, Inc. | Unresolved — no canonical attribution shown | $3.02 | 0.6% | 2 | 2025 |
What were the payments for?
Payment categories
| Category | Amount | Records |
|---|---|---|
| Food and Beverage | $493.94 | 19 |
| Education | $3.02 | 2 |
A meal, consulting fee, royalty, and travel payment describe different kinds of reported relationships and should not be interpreted as equivalent.
Analysis 1 · Payment-linked products
Products named in Open Payments records
| Reported product | Type | Reported company | Related amount* | Records | Year |
|---|---|---|---|---|---|
| Nubeqa Normalized: nubeqa |
Drug | Bayer Healthcare Pharmaceuticals Inc. | $109.65 | 1 | 2025 |
Source payment records
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| Xtandi Normalized: xtandi |
Drug | Astellas Pharma US Inc | $52.80 | 2 | 2025 |
Source payment records
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| ERLEADA Normalized: erleada |
Drug | Janssen Biotech, Inc. | $51.40 | 2 | 2025 |
Source payment records
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| XIAFLEX Normalized: xiaflex |
Biological | Endo USA, Inc. | $49.30 | 2 | 2025 |
Source payment records
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| LUPRON DEPOT Normalized: lupron depot |
Drug | ABBVIE INC. | $25.14 | 1 | 2025 |
Source payment records
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| STRAVIX Normalized: stravix |
Biological | Smith+Nephew, Inc. | $23.83 | 1 | 2025 |
Source payment records
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| BIOPROTECT BALLOON IMPLANT SYSTEM Normalized: bioprotect balloon implant system |
Device | BIOPROTECT MEDICAL, INC. | $23.20 | 1 | 2025 |
Source payment records
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| AQUABEAM ROBOTIC SYSTEM Normalized: aquabeam robotic system |
Device | Procept Biorobotics Corporation | $22.24 | 1 | 2025 |
Source payment records
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| INTERSTIM Normalized: interstim |
Device | Medtronic, Inc. | $18.85 | 1 | 2025 |
Source payment records
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| ORGOVYX Normalized: orgovyx |
Drug | Sumitomo Pharma America, Inc. | $18.08 | 1 | 2025 |
Source payment records
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| ADSTILADRIN Normalized: adstiladrin |
Biological | Ferring Pharmaceuticals Inc. | $17.24 | 1 | 2025 |
Source payment records
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| CVAC ASPIRATION SYSTEM Normalized: cvac aspiration system |
Device | Calyxo, Inc. | $17.02 | 1 | 2025 |
Source payment records
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| PYLARIFY Normalized: pylarify |
Drug | PROGENICS PHARMACEUTICALS, INC. | $16.79 | 1 | 2025 |
Source payment records
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| NANOKNIFE Normalized: nanoknife |
Device | AngioDynamics, Inc. | $16.66 | 1 | 2025 |
Source payment records
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| SpaceOAR VUE System - 10mL Normalized: spaceoar vue system 10ml |
Device | Boston Scientific Corporation | $16.40 | 1 | 2025 |
Source payment records
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| Thiola Normalized: thiola |
Drug | Travere Therapeutics, Inc. | $3.02 | 2 | 2025 |
Source payment records
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* Product-associated amounts are non-additive because one payment record may name more than one product.
These products were named on specific Open Payments records. A named product does not show that the payment influenced treatment or prescribing.
Public prescribing for products named in payments
| Open Payments product | Payment year | Part D brand | Part D year | Claims | Match method | Source |
|---|---|---|---|---|---|---|
| Xtandi xtandi |
2025 | Xtandi | 2024 | 12 Beneficiary count suppressed |
exact normalized | Medicare Part D |
The presence of the same drug in both datasets does not show that a payment caused or influenced a prescription.
Analysis 2 · Same-company prescribing overlap
Drugs reported in other payments from the same company that also appear in Medicare Part D
This analysis is independent from products named on this doctor’s individual payment records. A row appears only when the exact Open Payments reporting entity paid this doctor, that same reporting entity reported the drug or biological on at least 10 loaded General Payment records involving at least 2 distinct recipient NPIs, and this doctor has the same non-generic brand in public Part D data. This does not mean the company owns or manufactures the drug.
| Paying company | Payment year | Drug reported by same entity | Open Payments evidence | Part D | Claims | Beneficiaries |
|---|---|---|---|---|---|---|
| Astellas Pharma US Inc Exact reporting entity; no affiliate inference |
2025 | Myrbetriq open payments reported associated product |
CMS Open Payments — General Payments 16 supporting records · 16 recipient NPIs · example record 1238599014 |
Myrbetriq · 2024 Exact normalized brand match · 1 Part D row |
152 | 51 |
| Astellas Pharma US Inc Exact reporting entity; no affiliate inference |
2025 | Xtandi open payments reported associated product |
CMS Open Payments — General Payments 11345 supporting records · 5418 recipient NPIs · example record 1238560686 |
Xtandi · 2024 Exact normalized brand match · 1 Part D row |
12 | suppressed by CMS |
| Sumitomo Pharma America, Inc. Exact reporting entity; no affiliate inference |
2025 | GEMTESA open payments reported associated product |
CMS Open Payments — General Payments 61692 supporting records · 22152 recipient NPIs · example record 1176593503 |
Gemtesa · 2024 Exact normalized brand match · 1 Part D row |
147 | 37 |
These facts do not show that a payment was for the drug, that the company owns or manufactures the drug, or that a payment caused or influenced prescribing.
Public Medicare Part D data
Provider-and-drug rows loaded for 2024
| Brand | Generic | Claims | Beneficiaries |
|---|---|---|---|
| Tamsulosin Hcl | Tamsulosin Hcl | 1022 | 310 |
| Finasteride | Finasteride | 599 | 183 |
| Alfuzosin Hcl Er | Alfuzosin Hcl | 174 | 55 |
| Myrbetriq | Mirabegron | 152 | 51 |
| Gemtesa | Vibegron | 147 | 37 |
| Silodosin | Silodosin | 96 | 36 |
| Tramadol Hcl | Tramadol Hcl | 75 | 67 |
| Ciprofloxacin Hcl | Ciprofloxacin Hcl | 55 | 49 |
| Dutasteride | Dutasteride | 54 | 16 |
| Testosterone | Testosterone | 44 | suppressed |
| Oxybutynin Chloride Er | Oxybutynin Chloride | 43 | 13 |
| Clotrimazole-Betamethasone | Clotrimazole/Betamethasone Dip | 38 | 18 |
| Hydrocodone-Acetaminophen | Hydrocodone/Acetaminophen | 35 | 30 |
| Imipramine Hcl | Imipramine Hcl | 34 | 13 |
| Sulfamethoxazole-Trimethoprim | Sulfamethoxazole/Trimethoprim | 32 | 28 |
| Methenamine Hippurate | Methenamine Hippurate | 29 | suppressed |
| Nitrofurantoin Mono-Macro | Nitrofurantoin Monohyd/M-Cryst | 29 | 18 |
| Estradiol | Estradiol | 26 | 19 |
| Potassium Citrate Er | Potassium Citrate | 26 | 11 |
| Oxycodone Hcl | Oxycodone Hcl | 25 | 25 |
| Cefadroxil | Cefadroxil | 22 | 20 |
| Oxybutynin Chloride | Oxybutynin Chloride | 14 | suppressed |
| Doxazosin Mesylate | Doxazosin Mesylate | 13 | suppressed |
| Fesoterodine Fumarate Er | Fesoterodine Fumarate | 13 | suppressed |
| Xtandi | Enzalutamide | 12 | suppressed |
| Amoxicillin | Amoxicillin | 11 | suppressed |
| Testosterone Cypionate | Testosterone Cypionate | 11 | suppressed |
Timeline
Payment and prescribing data by year
Open Payments and Medicare Part D may refer to different years. They are shown separately rather than aligned as if they describe the same period.
| Year | General Payments | Main payer | Explicit products | Company overlaps | Part D coverage |
|---|---|---|---|---|---|
| 2025 | $496.96 · 21 records | Bayer Healthcare Pharmaceuticals Inc. | ADSTILADRIN, AQUABEAM ROBOTIC SYSTEM, BIOPROTECT BALLOON IMPLANT SYSTEM, CVAC ASPIRATION SYSTEM, ERLEADA, INTERSTIM, LUPRON DEPOT, NANOKNIFE, Nubeqa, ORGOVYX, PYLARIFY, STRAVIX, SpaceOAR VUE System - 10mL, Thiola, XIAFLEX, Xtandi | 3 | — |
| 2024 | — | — | — | — | Complete |
Questions to ask
Questions you could discuss with your doctor
- What role, if any, does Xtandi play in your treatment recommendations for me?
- How do you evaluate evidence when you have a financial relationship with Astellas Pharma US Inc?
- Are there reasonable alternatives I should understand when we discuss treatment options?
- How should I interpret the industry-payment records shown here in the context of my care?
These are general questions generated from reviewed templates. They are not personalized medical advice.
Sources and limitations
How to read this page
- Payment and Medicare prescribing data can cover different years; every comparison shows both years explicitly.
- Part D does not represent a doctor’s entire practice; it excludes many patients and is subject to CMS public-release thresholds.
- Company–drug relationships must have an auditable source, a precise relationship type, and a valid evidence period. Unresolved mappings are not published.
- Generic drug claims are not attributed to a specific manufacturer without manufacturer-level evidence.
- When a source extract is incomplete, missing rows are never treated as proof of no payments or no prescriptions.
Loaded source releases
| Dataset | Year | Publication | Source |
|---|---|---|---|
| CMS Open Payments — General Payments | 2025 | 2026-06-30 | Original source |
| Medicare Part D Prescribers by Provider and Drug | 2024 | 2026-05-06 | Original source |
| NPPES Data Dissemination V2 | current / reference data | 2026-08-10 | Original source |
Full methodology · Questions & answers · Report a possible error