Payment overview · 2025
General Payments
$45.07
2 reported records · 2 companies
Healthcare provider profile · identity verified
Angie Layme, MD
Allopathic & Osteopathic Physicians|General Practice · SPRING HILL, FL · NPI 1962982785
Verified facts
What the public records show
CMS Open Payments records show Angie Layme, MD received $45.07 in general payments during 2025 across 2 reported records.
AstraZeneca Pharmaceuticals LP accounted for 60.2% of that reported general-payment amount.
The Open Payments records used for this analysis explicitly named 2 associated products.
AstraZeneca Pharmaceuticals LP reported payments to this doctor in 2025. Across the 2025 Open Payments General Payment records loaded for this analysis, that same reporting entity reported FARXIGA as an associated drug or biological on 106133 records involving 42906 distinct recipient NPIs. Public Medicare Part D data also shows 32 claims for Farxiga by this doctor in 2024.
AstraZeneca Pharmaceuticals LP reported payments to this doctor in 2025. Across the 2025 Open Payments General Payment records loaded for this analysis, that same reporting entity reported SYMBICORT as an associated drug or biological on 71 records involving 51 distinct recipient NPIs. Public Medicare Part D data also shows 11 claims for Symbicort by this doctor in 2024.
These records do not establish that a payment influenced prescribing or medical care.
Separate record types
Research & Ownership
Research Payments (direct recipient): not present in the loaded data
Associated Research Funding (for example, named PI): not present in the loaded data
Ownership / Investment: not present in the loaded data
These categories are never added into the General Payments headline. Associated research funding must not be described as money the doctor personally received unless the source record supports that conclusion.
Who paid this doctor?
Companies in 2025 General Payments
| Reported company | Canonical company | Amount | Share | Records | Year |
|---|---|---|---|---|---|
| AstraZeneca Pharmaceuticals LP | Unresolved — no canonical attribution shown | $27.14 | 60.2% | 1 | 2025 |
| Tonix Medicines, Inc. | Unresolved — no canonical attribution shown | $17.93 | 39.8% | 1 | 2025 |
What were the payments for?
Payment categories
| Category | Amount | Records |
|---|---|---|
| Food and Beverage | $45.07 | 2 |
A meal, consulting fee, royalty, and travel payment describe different kinds of reported relationships and should not be interpreted as equivalent.
Analysis 1 · Payment-linked products
Products named in Open Payments records
| Reported product | Type | Reported company | Related amount* | Records | Year |
|---|---|---|---|---|---|
| BREZTRI Normalized: breztri |
Drug | AstraZeneca Pharmaceuticals LP | $27.14 | 1 | 2025 |
Source payment records
|
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| TONMYA Normalized: tonmya |
Drug | Tonix Medicines, Inc. | $17.93 | 1 | 2025 |
Source payment records
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* Product-associated amounts are non-additive because one payment record may name more than one product.
These products were named on specific Open Payments records. A named product does not show that the payment influenced treatment or prescribing.
Public prescribing for products named in payments
No exact normalized or approved-alias overlap was found in the loaded Part D year. This does not mean the doctor never prescribed the product.
The presence of the same drug in both datasets does not show that a payment caused or influenced a prescription.
Analysis 2 · Same-company prescribing overlap
Drugs reported in other payments from the same company that also appear in Medicare Part D
This analysis is independent from products named on this doctor’s individual payment records. A row appears only when the exact Open Payments reporting entity paid this doctor, that same reporting entity reported the drug or biological on at least 10 loaded General Payment records involving at least 2 distinct recipient NPIs, and this doctor has the same non-generic brand in public Part D data. This does not mean the company owns or manufactures the drug.
| Paying company | Payment year | Drug reported by same entity | Open Payments evidence | Part D | Claims | Beneficiaries |
|---|---|---|---|---|---|---|
| AstraZeneca Pharmaceuticals LP Exact reporting entity; no affiliate inference |
2025 | FARXIGA open payments reported associated product |
CMS Open Payments — General Payments 106133 supporting records · 42906 recipient NPIs · example record 1206131362 |
Farxiga · 2024 Exact normalized brand match · 1 Part D row |
32 | suppressed by CMS |
| AstraZeneca Pharmaceuticals LP Exact reporting entity; no affiliate inference |
2025 | SYMBICORT open payments reported associated product |
CMS Open Payments — General Payments 71 supporting records · 51 recipient NPIs · example record 1206132610 |
Symbicort · 2024 Exact normalized brand match · 1 Part D row |
11 | suppressed by CMS |
These facts do not show that a payment was for the drug, that the company owns or manufactures the drug, or that a payment caused or influenced prescribing.
Public Medicare Part D data
Provider-and-drug rows loaded for 2024
| Brand | Generic | Claims | Beneficiaries |
|---|---|---|---|
| Atorvastatin Calcium | Atorvastatin Calcium | 843 | 259 |
| Levothyroxine Sodium | Levothyroxine Sodium | 653 | 184 |
| Omeprazole | Omeprazole | 536 | 183 |
| Gabapentin | Gabapentin | 498 | 183 |
| Alprazolam | Alprazolam | 476 | 100 |
| Lisinopril | Lisinopril | 476 | 165 |
| Losartan Potassium | Losartan Potassium | 403 | 127 |
| Metformin Hcl | Metformin Hcl | 348 | 106 |
| Amlodipine Besylate | Amlodipine Besylate | 346 | 108 |
| Tramadol Hcl | Tramadol Hcl | 334 | 92 |
| Rosuvastatin Calcium | Rosuvastatin Calcium | 320 | 99 |
| Albuterol Sulfate Hfa | Albuterol Sulfate | 318 | 126 |
| Simvastatin | Simvastatin | 295 | 89 |
| Alendronate Sodium | Alendronate Sodium | 255 | 89 |
| Metoprolol Tartrate | Metoprolol Tartrate | 230 | 72 |
| Pantoprazole Sodium | Pantoprazole Sodium | 224 | 64 |
| Trazodone Hcl | Trazodone Hcl | 220 | 70 |
| Furosemide | Furosemide | 208 | 81 |
| Citalopram Hbr | Citalopram Hydrobromide | 207 | 68 |
| Tizanidine Hcl | Tizanidine Hcl | 205 | 82 |
| Fluticasone Propionate | Fluticasone Propionate | 184 | 81 |
| Pregabalin | Pregabalin | 177 | 41 |
| Glimepiride | Glimepiride | 169 | 60 |
| Sertraline Hcl | Sertraline Hcl | 169 | 50 |
| Zolpidem Tartrate | Zolpidem Tartrate | 167 | 32 |
| Montelukast Sodium | Montelukast Sodium | 166 | 58 |
| Hydrochlorothiazide | Hydrochlorothiazide | 165 | 56 |
| Hydrocodone-Acetaminophen | Hydrocodone/Acetaminophen | 162 | 50 |
| Clopidogrel | Clopidogrel Bisulfate | 160 | 52 |
| Clonazepam | Clonazepam | 155 | 35 |
| Tamsulosin Hcl | Tamsulosin Hcl | 143 | 43 |
| Metoprolol Succinate | Metoprolol Succinate | 141 | 44 |
| Potassium Chloride | Potassium Chloride | 140 | 47 |
| Meloxicam | Meloxicam | 139 | 50 |
| Temazepam | Temazepam | 138 | 22 |
| Atenolol | Atenolol | 136 | 41 |
| Glipizide | Glipizide | 121 | 34 |
| Meclizine Hcl | Meclizine Hcl | 118 | 42 |
| Duloxetine Hcl | Duloxetine Hcl | 111 | 37 |
| Ezetimibe | Ezetimibe | 107 | 31 |
| Carvedilol | Carvedilol | 104 | 32 |
| Pravastatin Sodium | Pravastatin Sodium | 103 | 30 |
| Buspirone Hcl | Buspirone Hcl | 102 | 41 |
| Methylprednisolone | Methylprednisolone | 101 | 91 |
| Lisinopril-Hydrochlorothiazide | Lisinopril/Hydrochlorothiazide | 94 | 22 |
| Ciprofloxacin Hcl | Ciprofloxacin Hcl | 89 | 73 |
| Trelegy Ellipta | Fluticasone/Umeclidin/Vilanter | 89 | 21 |
| Eliquis | Apixaban | 82 | 24 |
| Donepezil Hcl | Donepezil Hcl | 80 | 26 |
| Famotidine | Famotidine | 79 | 31 |
| Testosterone Cypionate | Testosterone Cypionate | 78 | 21 |
| Ibuprofen | Ibuprofen | 72 | 28 |
| Prednisone | Prednisone | 68 | 56 |
| Allopurinol | Allopurinol | 66 | 20 |
| Azithromycin | Azithromycin | 64 | 61 |
| Isosorbide Mononitrate Er | Isosorbide Mononitrate | 63 | 21 |
| Pioglitazone Hcl | Pioglitazone Hcl | 62 | 19 |
| Bupropion Xl | Bupropion Hcl | 60 | 23 |
| Lorazepam | Lorazepam | 60 | 14 |
| Ondansetron Hcl | Ondansetron Hcl | 60 | 29 |
| Lantus Solostar | Insulin Glargine,hum.Rec.Anlog | 58 | 17 |
| Doxycycline Monohydrate | Doxycycline Monohydrate | 57 | 52 |
| Finasteride | Finasteride | 57 | 19 |
| Propranolol Hcl | Propranolol Hcl | 57 | 19 |
| Ketoconazole | Ketoconazole | 56 | 23 |
| Losartan-Hydrochlorothiazide | Losartan/Hydrochlorothiazide | 55 | 15 |
| Cyclobenzaprine Hcl | Cyclobenzaprine Hcl | 54 | 16 |
| Oxybutynin Chloride Er | Oxybutynin Chloride | 54 | 21 |
| Triamcinolone Acetonide | Triamcinolone Acetonide | 54 | 24 |
| Lovastatin | Lovastatin | 52 | 18 |
| Spironolactone | Spironolactone | 52 | 14 |
| Amoxicillin | Amoxicillin | 50 | 47 |
| Nystatin | Nystatin | 50 | 23 |
| Baclofen | Baclofen | 48 | 14 |
| Escitalopram Oxalate | Escitalopram Oxalate | 47 | 16 |
| Diazepam | Diazepam | 46 | 12 |
| Fluticasone-Salmeterol | Fluticasone Propion/Salmeterol | 46 | 14 |
| Warfarin Sodium | Warfarin Sodium | 46 | 11 |
| Breo Ellipta | Fluticasone/Vilanterol | 42 | suppressed |
| Gemfibrozil | Gemfibrozil | 42 | 11 |
| Dabigatran Etexilate | Dabigatran Etexilate Mesylate | 38 | 11 |
| Paroxetine Hcl | Paroxetine Hcl | 38 | 12 |
| Nitroglycerin | Nitroglycerin | 37 | 18 |
| Ozempic | Semaglutide | 36 | suppressed |
| Ropinirole Hcl | Ropinirole Hcl | 36 | 15 |
| Hydralazine Hcl | Hydralazine Hcl | 35 | suppressed |
| Butalbital-Acetaminophen-Caffe | Butalb/Acetaminophen/Caffeine | 33 | suppressed |
| Fluoxetine Hcl | Fluoxetine Hcl | 33 | suppressed |
| Januvia | Sitagliptin Phosphate | 33 | suppressed |
| Enalapril Maleate | Enalapril Maleate | 32 | suppressed |
| Farxiga | Dapagliflozin Propanediol | 32 | suppressed |
| Clonidine Hcl | Clonidine Hcl | 31 | 13 |
| Cephalexin | Cephalexin | 30 | 28 |
| Sildenafil Citrate | Sildenafil Citrate | 30 | suppressed |
| Quetiapine Fumarate | Quetiapine Fumarate | 29 | 13 |
| Fenofibrate | Fenofibrate | 28 | suppressed |
| Jardiance | Empagliflozin | 28 | suppressed |
| Mirtazapine | Mirtazapine | 28 | suppressed |
| Oxycodone-Acetaminophen | Oxycodone Hcl/Acetaminophen | 28 | suppressed |
| Sumatriptan Succinate | Sumatriptan Succinate | 28 | suppressed |
| Valsartan-Hydrochlorothiazide | Valsartan/Hydrochlorothiazide | 26 | suppressed |
| Fluconazole | Fluconazole | 25 | 20 |
| Naproxen | Naproxen | 25 | suppressed |
| Ondansetron Odt | Ondansetron | 25 | 14 |
| Myrbetriq | Mirabegron | 24 | suppressed |
| Oxybutynin Chloride | Oxybutynin Chloride | 24 | suppressed |
| Acyclovir | Acyclovir | 23 | 14 |
| Hydroxyzine Hcl | Hydroxyzine Hcl | 23 | suppressed |
| Labetalol Hcl | Labetalol Hcl | 23 | suppressed |
| Spiriva Handihaler | Tiotropium Bromide | 23 | suppressed |
| Venlafaxine Hcl Er | Venlafaxine Hcl | 23 | suppressed |
| Valacyclovir | Valacyclovir Hcl | 22 | suppressed |
| Esomeprazole Magnesium | Esomeprazole Magnesium | 21 | suppressed |
| Topiramate | Topiramate | 21 | suppressed |
| Doxepin Hcl | Doxepin Hcl | 20 | suppressed |
| Levetiracetam | Levetiracetam | 20 | suppressed |
| Primidone | Primidone | 20 | suppressed |
| Venlafaxine Hcl | Venlafaxine Hcl | 20 | suppressed |
| Benzonatate | Benzonatate | 19 | 16 |
| Folic Acid | Folic Acid | 19 | suppressed |
| Memantine Hcl | Memantine Hcl | 19 | suppressed |
| Midodrine Hcl | Midodrine Hcl | 19 | suppressed |
| Trulicity | Dulaglutide | 19 | suppressed |
| Diltiazem 24hr Er (Cd) | Diltiazem Hcl | 18 | suppressed |
| Tradjenta | Linagliptin | 18 | suppressed |
| Diltiazem Hcl | Diltiazem Hcl | 17 | suppressed |
| Divalproex Sodium | Divalproex Sodium | 17 | suppressed |
| Levofloxacin | Levofloxacin | 17 | 15 |
| Nifedipine Er | Nifedipine | 17 | suppressed |
| Terazosin Hcl | Terazosin Hcl | 17 | suppressed |
| Triamterene-Hydrochlorothiazid | Triamterene/Hydrochlorothiazid | 17 | suppressed |
| Clotrimazole-Betamethasone | Clotrimazole/Betamethasone Dip | 16 | suppressed |
| Morphine Sulfate Er | Morphine Sulfate | 16 | suppressed |
| Mupirocin | Mupirocin | 16 | suppressed |
| Nitrofurantoin | Nitrofurantoin Macrocrystal | 16 | 15 |
| Nitrofurantoin Mono-Macro | Nitrofurantoin Monohyd/M-Cryst | 16 | 15 |
| Novolog Flexpen | Insulin Aspart | 16 | suppressed |
| Sulfamethoxazole-Trimethoprim | Sulfamethoxazole/Trimethoprim | 16 | 15 |
| Ultra-Fine Short Pen Needle | Pen Needle, Diabetic | 16 | suppressed |
| Fenofibrate | Fenofibrate,micronized | 15 | suppressed |
| Lantus | Insulin Glargine,hum.Rec.Anlog | 15 | suppressed |
| Oxycodone Hcl | Oxycodone Hcl | 15 | suppressed |
| Tadalafil | Tadalafil | 15 | suppressed |
| Xarelto | Rivaroxaban | 15 | suppressed |
| Amiodarone Hcl | Amiodarone Hcl | 14 | suppressed |
| Benazepril Hcl | Benazepril Hcl | 14 | suppressed |
| Breyna | Budesonide/Formoterol Fumarate | 14 | suppressed |
| Wixela Inhub | Fluticasone Propion/Salmeterol | 14 | suppressed |
| Bumetanide | Bumetanide | 13 | suppressed |
| Diclofenac Sodium | Diclofenac Sodium | 13 | suppressed |
| Dicyclomine Hcl | Dicyclomine Hcl | 13 | suppressed |
| Entresto | Sacubitril/Valsartan | 13 | suppressed |
| Lactulose | Lactulose | 13 | suppressed |
| Metronidazole | Metronidazole | 13 | 13 |
| Novolin 70-30 | Insulin Nph Hum/Reg Insulin Hm | 13 | suppressed |
| Rizatriptan | Rizatriptan Benzoate | 13 | suppressed |
| Sure Comfort | Syringe-Needle,insulin,0.5 Ml | 13 | suppressed |
| Ursodiol | Ursodiol | 13 | suppressed |
| Carbidopa-Levodopa | Carbidopa/Levodopa | 12 | suppressed |
| Celecoxib | Celecoxib | 12 | suppressed |
| Cilostazol | Cilostazol | 12 | suppressed |
| Mounjaro | Tirzepatide | 12 | suppressed |
| Nano 2nd Gen Pen Needle | Pen Needle, Diabetic | 12 | suppressed |
| Ramipril | Ramipril | 12 | suppressed |
| Ranolazine Er | Ranolazine | 12 | suppressed |
| Synthroid | Levothyroxine Sodium | 12 | suppressed |
| Amoxicillin-Clavulanate Potass | Amoxicillin/Potassium Clav | 11 | suppressed |
| Bisoprolol Fumarate | Bisoprolol Fumarate | 11 | suppressed |
| Diclofenac Potassium | Diclofenac Potassium | 11 | suppressed |
| Indomethacin | Indomethacin | 11 | suppressed |
| Lansoprazole | Lansoprazole | 11 | suppressed |
| Morphine Sulfate | Morphine Sulfate | 11 | suppressed |
| Olmesartan Medoxomil | Olmesartan Medoxomil | 11 | suppressed |
| Symbicort | Budesonide/Formoterol Fumarate | 11 | suppressed |
| Tresiba Flextouch U-200 | Insulin Degludec | 11 | suppressed |
| Verapamil Er | Verapamil Hcl | 11 | suppressed |
Timeline
Payment and prescribing data by year
Open Payments and Medicare Part D may refer to different years. They are shown separately rather than aligned as if they describe the same period.
| Year | General Payments | Main payer | Explicit products | Company overlaps | Part D coverage |
|---|---|---|---|---|---|
| 2025 | $45.07 · 2 records | AstraZeneca Pharmaceuticals LP | BREZTRI, TONMYA | 2 | — |
| 2024 | — | — | — | — | Complete |
Questions to ask
Questions you could discuss with your doctor
- How do you evaluate evidence when you have a financial relationship with AstraZeneca Pharmaceuticals LP?
- Are there reasonable alternatives I should understand when we discuss treatment options?
- How should I interpret the industry-payment records shown here in the context of my care?
These are general questions generated from reviewed templates. They are not personalized medical advice.
Sources and limitations
How to read this page
- Payment and Medicare prescribing data can cover different years; every comparison shows both years explicitly.
- Part D does not represent a doctor’s entire practice; it excludes many patients and is subject to CMS public-release thresholds.
- Company–drug relationships must have an auditable source, a precise relationship type, and a valid evidence period. Unresolved mappings are not published.
- Generic drug claims are not attributed to a specific manufacturer without manufacturer-level evidence.
- When a source extract is incomplete, missing rows are never treated as proof of no payments or no prescriptions.
Loaded source releases
| Dataset | Year | Publication | Source |
|---|---|---|---|
| CMS Open Payments — General Payments | 2025 | 2026-06-30 | Original source |
| Medicare Part D Prescribers by Provider and Drug | 2024 | 2026-05-06 | Original source |
| NPPES Data Dissemination V2 | current / reference data | 2026-08-10 | Original source |
Full methodology · Questions & answers · Report a possible error